Ấn phẩm

Isolation, Structural Determination, and Cytotoxicity of Compounds from the Non-Alkaloid Extract of Cinnamomum bejolghota (Journal of Medicinal Materials, 2024, Vol. 29, No. 2)

Journal of Medicinal Materials, 2024, Vol. 29, No. 2 (pp. 87 - 92)

ISOLATION, STRUCTURAL DETERMINATION, AND CYTOTOXICITY

OF COMPOUNDS FROM THE NON-ALKALOID EXTRACT

OF CINNAMOMUM BEJOLGHOTA

Le Thi Phuong ^1, ², Trinh Thi Thanh Van¹, Nguyen Thuy Linh¹, Pham Van Cuong ^1, ²,

Doan Thi Mai Huong ¹ ^, ²^,*, Truong Bich Ngan ¹^{, 2,}*

¹ Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam

²Graduate University of Science and Technology, VAST, Hanoi, Vietnam

*Corresponding author: huongdm@imbc.vast.vn

(Received December 06^th, 2023)

Summary

Isolation, Structural Determination, and Cytotoxicity of Compounds from the Non-Alkaloid Extract

of Cinnamomum bejolghota

Eight compounds were isolated from the non-alkaloid extract of Cinnamomum bejolghota stem bark. Their chemical structures were elucidated as ergosta-4,6,8(14),22-tetraen-3-one (1), spathulenol (2), 5,7-dimethoxy-3',4'-methylenedioxyflavan-3-ol (3), afzelin (4), 3,4-dimethoxycinnamyl alcohol (5), 3,4-dimethoxycinnamaldehyde (6), veratraldehyde (7), and veratric acid (8) on the basis of detailed analysis of the 1D and 2D NMR spectroscopic data in comparison with the literature data. Compound 1 showed activity against the HepG-2 cell line with an IC₅₀ value of 21.8 µM. Compound 3 showed weak cytotoxic activity against KB, MCF-7, HepG-2, and SK-LU-1 human cancer cell lines with IC₅₀ values of 118.3, 110.7, 90.2, and 95.8 µM, respectively. Compounds 1 and 4 were reported from this plant for the first time.