Ấn phẩm

PTP1B Inhibitory Activity of Diterpenoids Isolated from Tetracera scandens (Journal of Medicinal Materials, 2017, Vol. 22, No. 5)

Journal of Medicinal Materials, 2017, Vol. 22, No. 5 (pp. 283 - 287)

 

 

PTP1B INHIBITORY ACTIVITY OF DITERPENOIDS ISOLATED FROM TETRACERA SCANDENS

Hoang Duc Manh1,*, Tran Minh Ngoc1, Jong Seog Ahn2

1National Institute of Medicinal Materials, Hanoi, Vietnam;

 2Korea Research Institute of Bioscience and Biotechnology (KRIBB)

*Corresponding author: manhhd@gmail.com

(Received August, 24th, 2017)

Summary

PTP1B Inhibitory Activity of Diterpenoids Isolated from Tetracera scandens

Protein tyrosine phosphatase 1B (PTP1B) is considered as a potential therapeutic target for the treatment of diabetes and obesity. In the course of our ongoing project to isolate PTP1B inhibitory compounds from medicinal plants, a new beyrane-type diterpenoid, ent–beyer–15–en–17–ol–19–oic acid (1), along with five known ent–kauranes, ent–18–acetoxy–7α–hydroxykaur–16–en–15–on (2), ent–(16S)–18–acetoxy–7α–hydroxykaur–16–en–15–on (3), ent–1α,7β–diacetoxy–14α–hydroxykaur–16–en–15– on (4), ent–1α,14α–diacetoxy–7β–hydroxykaur–16–en–15–on (5) and ent–1α– acetoxy–7β, and –14α–dihydroxykaur–16–en–15–on (6). The structures of these compounds were identified on the basic of extensive 1D and 2D NMR studies. Compound 1 showed PTP1B inhibitory activity with IC50 value of 11.2 μM while the IC50 values of compounds 2–6 ranged from 41.3 to 74.1 μM.

Keywords: Tetracera scandens, Dilleniaceae, Ent–beyrane diterpene, Protein tyrosine phosphatase 1B (PTP1B), Diabetes.

 

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