Journal of Medicinal Materials, 2018, Vol. 23, No. 5 (pp. 259 - 263)
PENTACYCLIC TRITERPENES FROM THE ROOTS OF DANSHEN (SALVIA MILTIORRHIZA BUNGE) CULTIVATED IN VIETNAM
Le Quoc Hung1,2, Phuong Thien Thuong2, Nguyen Thanh Hai1, Nguyen Huu Tung1,*
1School of Medicine and Pharmacy, Vietnam National University, (VNU), Hanoi, Vietnam
2National Institute of Medicinal Materials (NIMM), Hanoi, Vietnam
*Corresponding author: tunginpc@gmail.com
(Received August, 10th, 2018)
Summary
Pentacyclic Triterpenes from the Roots of Danshen (Salvia miltiorrhiza Bunge) Cultivated in Vietnam
Danshen (Salvia miltiorrhiza Bunge) cultivated in the North-Western region of Vietnam including Lao Cai and Ha Giang provinces is one of the most important and highly valuable medicinal plants for both traditional use and modern medicine. In our study course on the selected medicinal materials of the North-Western region and as part of our research on bioactive compounds from Danshen, using chromatography methods resulted in the isolation of six pentacyclic triterpenes from the roots of Danshen collected in Lao Cai. Their chemical structures were identified as 7β,24-dihydroxy ursolic acid (1), epiasiatic acid (2), ursolic acid (3), oleanolic acid (4), maslinic acid (5) and asiatic acid (6), respectively, on the basis of spectroscopic data including mass spectrometry and nuclear magnetic resonance spectra and comparison with those reported in literatures. Among them, ursolic acid (3) exerted moderate cytotoxic effect and the triterpene 1 showed weak activity against HL-60. This is the first report of the two ursane-type triterpenes 1 and 2 from Danshen cultivated in Vietnam and 7β,24-dihydroxy ursolic acid (1) was first identified from the genus Salvia.
Keywords: Danshen, Salvia miltiorrhiza, Lamiaceae, Triterpenoid, Cytotoxicity.
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