Ấn phẩm

Phenolic Compounds and a Triterpenoid from the Stem Bark of Limonia acidissima Groff, Rutaceae Journal of Medicinal Materials, 2022, Vol. 27, No. 2

Journal of Medicinal Materials, 2022, Vol. 27, No. 2 (pp. 67 - 71)

 

PHENOLIC COMPOUNDS AND A TRITERPENOID

FROM THE STEM BARK OF LIMONIA ACIDISSIMA GROFF, RUTACEAE

Dang Thi Bao Tram, Nguyen Minh Tu, Tran Duy Hien, Nguyen Le Thanh Tuyen,

Do Thi Hong Tuoi, Tran Thi Van Anh*

Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City

*Corresponding author: ttvananh@ump.edu.vn

(Received March 15th, 2022)

Summary

Phenolic Compounds and a Triterpenoid from the Stem Bark of Limonia acidissima Groff, Rutaceae

In the continuing search for active compounds from the stem bark of Limonia acidissima, six compounds were isolated from the petroleum ether fraction which showed cytotoxicity in RD-A cell line (IC50 = 42.49 µg/mL). They are ethyl divaricatinate (1), sekikaic acid (2), bergapten (3), auraptene (4), lupeol (5), and daucosterol (6). Their structures were identified based on 1D-NMR, 2D-NMR, ESI-MS and spectroscopic comparison with previous reports. Compounds 1 and 2 were isolated from L. acidissima for the first time. Compounds 4 and 5 showed cytotoxicity in RD-A cell line with IC50­ values of 25.97 μM and 69.64 μM, respectively.

Keywords: Limonia acidissima, Ethyl divaricatinate, Sekikaic acid, Bergapten, Lupeol.

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