Journal of Medicinal Materials, 2022, Vol. 27, No. 2 (pp. 90 - 94)

PHENOLICS AND ALKALOIDS FROM THE FRUITS OF PIPER LONGUM L.

Nguyen Tra My¹, Nguyen Thi Thu¹, Vu Thi Diep¹, Hoang Thi Dieu Huong¹,

Nguyen Thi Hang¹, Nguyen Thi My Linh², Vu Duc Loi², Do Thi Ha^1,*

¹National Institute of Medicinal Materials (NIMM), Hanoi, Vietnam;

²VNU University of Medicine and Pharmacy, Hanoi, Vietnam

*Corresponding author: hado.nimms@gmail.com

(Received April 05^th, 2022)

Summary

Phenolics and Alkaloids from the Fruits of Piper longum L.

Seven compounds, including avenalumic acid methyl ester (1), methyl piperate (2), piperine (3), pipernonaline (4), (2E,4Z,8E)-N-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl] piperidine (5), pipercide (6), and guineensine (7) were isolated from the ethyl acetate extract of Piper longum L. fruits. The structures of these compounds were identified by using extensive nuclear magnetic resonance spectroscopy (NMR) data, mass spectrometry (MS), and comparing with published literature. Compounds 1 and 6 were the first report from this species.

Keywords: Piper longum, Fruit, Phenolics, Alkaloids, Piperine.

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