Journal of Medicinal Materials, 2023, Vol. 28, No. 2 (pp. 99 - 103)
PHYTOCHEMICAL CHARACTERIZATION AND BIOACTIVITY EVALUATION OF ARDISIA SYLVESTRIS LEAVES FROM LAM BINH MOUNTAINOUS DISTRICT, TUYEN QUANG PROVINCE
Nguyen Trung Thanh1, Dang Hong Duyen1, Pham Thi Thu Trang1, Nguyen Thi Thu Minh1,
Nguyen Thi Hai2, Hua Van Luong3, Chu Quynh Mai 4, Doan Thi Phuong Ly4, Nguyen Thi Minh Hue4, Tran Thi Thanh Van4, Ngo Thi Thuy Ngan5, Nguyen Thi Thu Thuy6, Nguyen Tien Dat1, *, Do Hoang Giang1, *
1Center for Research and Technology Transfer, Vietnam Academy of Science and Technology;
2Ministry of Education and Training, Vietnam;
3Lam Binh Forest Protection Office, Tuyen Quang Province; 4Tan Trao University, Vietnam;
5Department of Fundamental Science, Thai Nguyen University of Medicine and Pharmacy, Vietnam;
6Joint Vietnam-Russia Tropical Science and Technology Research Center, Vietnam
*Corresponding author: ntdat@ctctt.vast.vn or dhgiang@ctctt.vast.vn
(Received March 08th, 2023)
Summary
Phytochemical Characterization and Bioactivity Evaluation of Ardisia sylvestris Leaves from Lam Binh Mountainous District, Tuyen Quang Province
Ardisia sylvestris Pitard is a common herb which has been used widely for abdominal pain treatment. In this study, several chemical constituents, the antioxidant and anti-inflammatory activities of A. sylvestris leaves collected from the Lam Binh mountainous district, Tuyen Quang province, have been evaluated and compared to those of the samples from the domestic traditional medicinal market. The results indicated that the total phenolic contents of A. sylvestris samples from the Lam Binh district ranged from 12.61 to 18.96 mg GAE/g, while their total flavonoid contents varied between 7.85 and 13.27 mg QE/g. These were significantly higher than the contents of phenolic and flavonoid compounds of the marketed samples. Total alkaloid and tannin contents of A. sylvestris leaves collected from the Lam Binh were 1.39 - 3.94 mg/g and 2.54 - 3.94%, respectively, which were equal to those of the marketed samples. Moreover, extracts of A. sylvestris leaves from Lam Binh districts exhibited considerable DPPH radical-scavenging activity with IC50 from 22.41 to 41.13 µg/mL, which were mostly higher than those of the positive control (ascorbic acid) and the market samples. Whereas, all samples demonstrated weak NO production inhibition without cytotoxicity in LPS-stimulated RAW264.7 macrophage cells. These were promising results for further investigation and cultivation of A. sylvestris in mountainous regions in the Lam Binh district as well as the other northern mountainous areas.
Keywords: Ardisia sylvestris, Antioxidant, Anti-inflammation.
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