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Phytochemical Screening and In vitro Biological Activities of Vernonia amygdalina Del. Leaves (Journal of Medicinal Materials, 2019, Vol. 24, No. 5)

Journal of Medicinal Materials, 2019, Vol. 24, No. 5 (pp.269 - 276)



Ly Hai Trieu1, Au Vinh Thanh Long1, Nguyen Thanh Truc1, Truong Trieu Minh1,
Nguyen Minh Thu1, Nguyen Thi Thu Huong1, Le Thanh Minh2, Le Van Minh1,*

1Research Center of Ginseng and Medicinal Materials -

National Institute of Medicinal Materials, Ho Chi Minh City, Vietnam;

2Nutrition - Food Safety Department, Institute of Public Health HCM City

*Corresponding author:  lvminh05@gmail.com or lvminh_hcm@nimm.org.vn

(Received August, 19th, 2019)


Phytochemical Screening and In vitro Biological Activities of Vernonia amygdalina Del. Leaves

Vernonia amygdalina Del. is an important and commonly used plant for its medicinal and pharmacological properties. The present study aimed to evaluate in vitro anti-urolithic, antibacterial, and anti-inflammatory activities of crude and fractionated extracts of V. amygdalina leaves. Results showed that V. amygdalina leaves contain flavonoids, alkaloids, tannins, triterpenoids, saponins, and anthraquinones. The crude ethanol extract, n-butanol, and aqueous fractions presented anti-urolithic through inhibition of calcium oxalate crystallization. All crude and fractionated extracts exhibited in vitro antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Simultaneously, results also showed that n-hexane, n-butanol, and aqueous fractions exhibited anti-inflammatory activity via inhibition of protein denaturation, in which n-butanol fraction has shown the highest activity with an IC50 value of 79.72 μg/mL, which was comparable with diclofenac sodium (168.17 μg/mL). Taken together, the present study has demonstrated that V. amygdalina leaf extract has properties that support urolithiasis disease.

Keywords: Vernonia amygdalina Del. leaves, Phytochemical screening, Anti-urolithic activity, Antibacterial activity, Anti-inflammatory activity.

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