Journal of Medicinal Materials, 2022, Vol. 27, No. 6 (pp. 350 - 356)

POLYPRENYLATED ACYLPHLOROGLUCINOLS FROM THE FRUIT PERICARP OF GARCINIA OBLONGIFOLIA AND THEIR CYTOTOXICITY

Nguyen Nghia Vu^1,3, Tran Thi Thu Thuy^2,*, Hoang Thi Minh Nguyet², Hoang Kim Chi²,

Tran Thi Hong Ha², Pham Hong Hanh¹, Phan Minh Giang^1,*

¹Faculty of Chemistry, VNU University of Science, VNU Hanoi, Hanoi, Vietnam;

²Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;

³Center for Research and Production of Vaccines and Biologicals, Ministry of Health, Hanoi, Vietnam

*Corresponding authors: thuy.tran@inpc.vast.vn or phanminhgiang@yahoo.com

(Received November 23^th, 2022)

Summary

Polyprenylated Acylphloroglucinols from the Fruit Pericarp of Garcinia oblongifolia

and their Cytotoxicity

The paper deals with chromatographic isolation, structural elucidation, and cytotoxic activity of compounds from the pericarp of Garcinia oblongifolia fruit. Four compounds, isogarcinol, oblongifolin A, garcinol, and 1,5-dimethyl citrate were isolated. Standard spectroscopic methods (MS, 1D and 2D NMR) were used in the evaluation of the structures of the four compounds. The SRB cytotoxicity test showed micromolar half-maximal inhibitory concentrations (IC₅₀) of isogarcinol against Hep-G2, HeLa, and Vero cell lines and garcinol against Hep-G2, HeLa, LU-1, and Vero cell lines.

Keywords: Garcinia oblongifolia, Acylphloroglucinol, Citrate, Cytotoxicity.

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