Journal of Medicinal Materials, 2022, Vol. 27, No. 1 (pp. 24 - 31)

QUALITY EVALUATION OF CENTELLA ASIATICA FROM

VARIED GEOGRAPHICAL AREAS IN VIETNAM

BY RP-HPLC/DAD AND CHEMOMETRICS

Nguyen Thi Ha Ly^1,*, Hoang Thi Tuyet¹, Nguyen Dieu Linh², Nguyen Quynh Nga¹,

Nguyen Minh Khoi¹, Do Thi Ha^1,*

¹ National Institute of Medicinal Materials (NIMM), Hanoi, Vietnam

²Faculty of Chemistry, VNU University of Science, Vietnam National University, Hanoi, Vietnam

*Corresponding authors: hado.nimms@gmail.com or nguyenthihaly.chem@gmail.com

(Received May 28^th, 2021)

Summary

Quality Evaluation of Centella asiatica from Varied Geographical Areas in Vietnam

by RP-HPLC/DAD and Chemometrics

Quality of Centella asiatica samples collected from varied geographical areas in Vietnam were evaluated based on non-target peaks and asiaticoside content by a reversed phase HPLC/DAD method. The results indicated that there are differences in the chemical compositions between the samples collected in different regions of Vietnam. The content of asiaticoside, a major bioactive compound of Centella asiatica, ranged from 0.07% to 1.19%. The PCA-DA method on the non-target peaks showed a fairly good classification for the samples collected in Red River Delta, Northeast, South and North Central regions.

Keywords: Centella asiatica, Asiaticoside, A reversed phase HPLC/DAD, Quality evaluation, Chemometrics

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