Journal of Medicinal Materials, 2023, Vol. 28, No. 6 (pp. 337 - 343)
SECONDARY METABOLITES FROM THE MARINE-DERIVED FUNGUS
ASPERGILLUS VERSICOLOR M852
Phi Thi Dao1, Le Thi Hong Minh1, Nguyen Mai Anh1, Nguyen Thuy Linh1,
Marie-Lise Bourguet-Kondracki2, Tran Dang Nguyen1, Pham Van Cuong1,3, Doan Thi Mai Huong1,3,*
1Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST);
2Muséum National d’Histoire Naturelle, Paris, France;
3Graduate University of Science and Technology, VAST, Vietnam
*Corresponding author: huongdm@imbc.vast.vn
(Received October 05th, 2023)
Summary
Secondary Metabolites from the Marine-Derived Fungus Aspergillus versicolor M852
Ten compounds were isolated from the culture of Aspergillus versicolor M852, an endophytic fungus isolated from the marine mollusca at Hon Cau 2, Binh Thuan, Vietnam. These compounds include (2R)-2,3-dihydro-7-hydroxy-6,8-dimethyl-2-[(E)-prop-1-enyl]-chroman-4-one (1), fumigaclavine I (2), fumigaclavine C (3), cyclo-(Pro-Phe) (4), cyclo-(Pro-Tyr) (5), cyclo-(Pro-Ala) (6), cyclo-(Pro-Val) (7), norharman (8), phloretic acid (9), and 3-phenylpropanoic acid (10). Their structures were identified through MS and NMR data analyses. These compounds were then assessed for their antimicrobial activity against a range of clinically significant microorganisms. Most of them exhibited inhibitory activity against one to three tested Gram-positive strains, with MIC values ranging from 64 to 256 µg/mL.
Keywords: Aspergillus versicolor, Antimicrobial activity, Dipeptide.
(Nguồn tin: )