Journal of Medicinal Materials, 2023, Vol. 28, No. 6 (pp. 337 - 343)

SECONDARY METABOLITES FROM THE MARINE-DERIVED FUNGUS

ASPERGILLUS VERSICOLOR M852

Phi Thi Dao¹, Le Thi Hong Minh¹, Nguyen Mai Anh¹, Nguyen Thuy Linh¹, 

Marie-Lise Bourguet-Kondracki², Tran Dang Nguyen¹, Pham Van Cuong^1,3, Doan Thi Mai Huong^1,3,*

¹Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST);

²Muséum National d’Histoire Naturelle, Paris, France;

³Graduate University of Science and Technology, VAST, Vietnam

*Corresponding author: huongdm@imbc.vast.vn

(Received October 05^th, 2023)

Summary

Secondary Metabolites from the Marine-Derived Fungus Aspergillus versicolor M852

Ten compounds were isolated from the culture of Aspergillus versicolor M852, an endophytic fungus isolated from the marine mollusca at Hon Cau 2, Binh Thuan, Vietnam. These compounds include (2R)-2,3-dihydro-7-hydroxy-6,8-dimethyl-2-[(E)-prop-1-enyl]-chroman-4-one (1), fumigaclavine I (2), fumigaclavine C (3), cyclo-(Pro-Phe) (4), cyclo-(Pro-Tyr) (5), cyclo-(Pro-Ala) (6), cyclo-(Pro-Val) (7), norharman (8), phloretic acid (9), and 3-phenylpropanoic acid (10). Their structures were identified through MS and NMR data analyses. These compounds were then assessed for their antimicrobial activity against a range of clinically significant microorganisms. Most of them exhibited inhibitory activity against one to three tested Gram-positive strains, with MIC values ranging from 64 to 256 µg/mL.

Keywords: Aspergillus versicolor, Antimicrobial activity, Dipeptide.

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