Journal of Medicinal Materials, 2022, Vol. 27, No. 2 (pp. 112 - 116)
STANDARDIZED FLAVONOID EXTRACT FROM DIOSPYROS KAKI L.F LEAVES IMPROVES DYSLIPIDEMIA IN HIGH-CHOLESTEROL DIET FED RATS
Nguyen Thị Thanh Loan1,2, Pham Thi Van Anh2, Le Thi Xoan1,*
1Department of Pharmacology and Biochemistry, National Institute of Medicinal Materials
2Department of Pharmacology, Hanoi Medical University
*Corresponding author: xoanle@nimm.org.vn
(Received March 29th, 2022)
Summary
Standardized Flavonoid Extract from Diospyros kaki l.f Leaves Improves Dyslipidemia in High-Cholesterol Diet Fed Rats
The current study designed to investigate the anti-dyslipidemia effects of the standardized flavonoid extract from Diospyros kaki L.f leaves (DK extract) in chronic high-cholesterol diet fed rats. Wistar rats were orally administered oil-cholesterol mixture. Rats were daily treated with DK extract (50 and 100 mg/kg of body weight; p.o.) or atorvastatin (10 mg/kg of body weight; p.o.) for 4 consecutive weeks. Body weight, serum lipid profiles, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were evaluated for every 2 weeks. Body weight was significantly increased in the DK extract-treated group compared to the vehicle-treated group. Treatment of DK extract decreased the serum total cholesterol, triglycerides, and non-high-density lipoprotein cholesterol levels, and increased the serum high-density lipoprotein cholesterol. Additionally, DK extract substantially diminished enzymatic activity serum AST and ALT which were increased in the hypercholesterolemia rats. Our finding suggested that DK extract improves dyslipidemia and liver function in high-cholesterol diet fed rats.
Keywords: Diospyros kaki L.f leaves, Flavonoid, High-cholesterol diet, Dyslipidemia.
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