Journal of Medicinal Materials, 2020, Vol. 25, No. 5 (pp. 299 - 303)
THE ANTI-INFLAMMATORY EFFECT OF PHYLLANTHUS EMBLICA FRUIT EXTRACT IN EXPERIMENTAL MODELS
OF ACUTE AND CHRONIC INFLAMMATION
Ngo Thanh Hoa1, Do Thi Ha2, Nguyen Thuy Duong1,*
1Hanoi University of Pharmacy, Vietnam;
2National Institute of Medicinal Materials, Vietnam
*Corresponding author: email@example.com
(Received June 02nd, 2020)
The Anti-Inflammatory Effect of Phyllanthus emblica Fruit Extract in Experimental Models
of Acute and Chronic Inflammation
Phyllanthus emblica (PE), a well-known medicinal plant, has been used in Asian countries for a long time. The present study aims to scientifically validate the traditional use of PE in the treatment of inflammatory disorders. Models of acute and chronic inflammation, namely carrageenan-induced rat paw edema and the cotton pellet granuloma in rats were used. In the model of carrageenan-induced paw edema, the extract of PE at the doses of 250 mg/kg and 500 mg/kg p.o showed a significant reduction in paw edema in comparison with control. In cotton pellet-induced granuloma, the extract of PE at the doses of 250 mg/kg and 500 mg/kg p.o significantly inhibited granuloma formation in rats.
Keywords: Phyllanthus emblica, Anti-inflammatory, Acute inflammation, Chronic inflammation.
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