Ấn phẩm

The Anti-Inflammatory Effect of Phyllanthus emblica Fruit Extract in Experimental Models of Acute and Chronic Inflammation (Journal of Medicinal Materials, 2020, Vol. 25, No. 5)

Journal of Medicinal Materials, 2020, Vol. 25, No. 5 (pp. 299 - 303)

 

THE ANTI-INFLAMMATORY EFFECT OF PHYLLANTHUS EMBLICA FRUIT EXTRACT IN EXPERIMENTAL MODELS

OF ACUTE AND CHRONIC INFLAMMATION

Ngo Thanh Hoa1, Do Thi Ha2, Nguyen Thuy Duong1,*

1Hanoi University of Pharmacy, Vietnam;

 2National Institute of Medicinal Materials, Vietnam

*Corresponding author: duongnt@hup.edu.vn

(Received June 02nd, 2020)

Summary

The Anti-Inflammatory Effect of Phyllanthus emblica Fruit Extract in Experimental Models

of Acute and Chronic Inflammation

Phyllanthus emblica (PE), a well-known medicinal plant, has been used in Asian countries for a long time. The present study aims to scientifically validate the traditional use of PE in the treatment of inflammatory disorders. Models of acute and chronic inflammation, namely carrageenan-induced rat paw edema and the cotton pellet granuloma in rats were used. In the model of carrageenan-induced paw edema, the extract of PE at the doses of 250 mg/kg and 500 mg/kg p.o showed a significant reduction in paw edema in comparison with control. In cotton pellet-induced granuloma, the extract of PE at the doses of 250 mg/kg and 500 mg/kg p.o significantly inhibited granuloma formation in rats.

Keywords: Phyllanthus emblica, Anti-inflammatory, Acute inflammation, Chronic inflammation.

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