Ấn phẩm

The Preparation of Diosmin from Hesperidin via three Steps (Tạp chí Dược liệu, tập 28, số 6/2023)

Journal of Medicinal Materials, 2023, Vol. 28, No. 6 (pp. 357 - 360)

 

THE PREPARATION OF DIOSMIN FROM HESPERIDIN
VIA THREE STEPS

Nguyen Thi Ha1,*, Hoang Thi Ngoc Anh2, Nguyen Minh Khoi1, Pham Hai Long1, Nguyen Thi Thuy Loan3

1National Institute of Medicinal Materials, Hanoi, Vietnam;  2Dai Nam University, Vietnam;

  3Edupharm International Joint Stock Company, Hanoi, Vietnam 

*Corresponding author: nguyenthihavdl2005@gmail.com

(Received May 19th, 2023)

Summary

The Preparation of Diosmin from Hesperidin via three Steps

Diosmin (diosmetin 7-O-rutinoside), the natural flavonoids mainly found in Citrus fruits, is used for the treatment of hemorrhoids or chronic venous diseases. In this report, we studied the semi-synthesis of diosmin from hesperidin through three steps. In the first step, hydroxyl functional groups of hesperidin were protected, then acetyl-hesperidin (1) was continuously oxidized on the C-3 position, diosmin was obtained by deacetylation reaction. The structure of compounds 1-3 was confirmed by 1D, 2D-NMR, and LC-ESI MS spectrum.

Keywords: Diosmin, Diosmetin 7-O-rutinoside, Hesperidin, Oxidation, Deacetylated.

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