Journal of Medicinal Materials, 2021, Vol. 26, No. 1+2 (pp. 95 - 101)
THE PROTECTIVE EFFECTS OF POLYSCIAS FRUTICOSA EXTRACTS AGAINST CHEMOTHERAPY DRUGS-INDUCED
Do Van Mai1,3, Nguyen Hoang Minh2, Ha Quang Thanh2, Mai Thanh Chung2,
Tran Cong Luan1, Nguyen Thi Thu Huong2,*
1Faculty of Pharmacy and Nurse, Tay Đo University, Vietnam;
2Research Center of Ginseng and Medicinal Materials in Ho Chi Minh City -
National Institute of Medicinal Materials, Hanoi, Vietnam;
3Faculty of Pharmacy, University of Medicine and Pharmacy, Ho Chi Minh City
*Corresponding author: email@example.com
(Received March 03rd, 2021)
The Protective Effects of Polyscias fruticosa Extracts Against Chemotherapy Drugs-Induced Hepatorenal Toxicity
Polyscias fruticosa (L.) Harms is one of the medicinal herbs in Araliaceae family that has been popular application in the health care. This study is to evaluate the protective effect of total and n-butanol extracts from P. fruticosa leaves and roots against chemotherapy drugs-induced hepatorenal toxicity by using the models of cisplatin-induced acute nephrotoxicity and cyclophosphamide-induced hepatotoxicity. The results showed that all extracts improved the hepatic-renal damages. P. fruticosa extracts, as well as quercetin, significantly decreased creatinine and urea levels in plasma, and malondialdehyde (MDA) levels in renal tissue of cisplatin-subjected mice. The n-butanol extract of P. fruticosa roots demonstrated the renal protective effect that was more typical than other extracts. Furthermore, oral administration of P. fruticosa extracts, as well as a reference drug silymarin, decreased MDA contents and increased glutathione (GSH) contents in liver of cyclophosphamide-subjected mice. This study suggests that P. fruticosa roots and leaves may be a potential candidate to ameliorate chemotherapy drugs-induced hepatorenal toxicity.
Keywords: Polyscias fruticosa (L.), Cyclophosphamide, Cisplatin, Hepatorenal protective effects.
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