Journal of Medicinal Materials, 2021, Vol. 26, No. 1+2 (pp. 79 - 83)
THE TOPICAL ANTI-INFLAMMATORY EFFECT OF A TSN-BASED GEL ON IN VIVO MODEL OF ACUTE INFLAMMATION
Nguyen Phuong Nga1, To Hien Minh1, Nguyen Phuong Nhung2,
Nguyen Ba Nghia3, Nguyen Thi Kieu Oanh1
1Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam,
Academy of Science and Technology;
2Hanoi University of Pharmacy; 3Innocare Pharmaceutical limited company, Hanoi, Vietnam
*Corresponding author: nguyen-thi-kieu.oanh@usth.edu.vn
(Received February 05th, 2021)
Summary
The Topical Anti-Inflammatory Effect of a TSN-Based Gel on in vivo Model of Acute Inflammation
The present study aims to investigate the potential of the combination of tannic acid-modified silver nanoparticles (TSN), pomegranate peel extract, chitosan and Oroxylum indicum leaf extract in PlasmaKare gel in the treatment of inflammatory disorders. In the model of acute inflammation by the croton oil in mouse, the TSN-based gel showed a significant reduction in mice ear edema in comparison with control. The gel with the presence of O. indicum leaf extract represented the better effect than without O. indicum, indicating the contribution of this extract to the in vivo anti-inflammatory activity. These products therefore could be developed for atopic dermatitis treatment.
Keywords: TSN, Pomegranate peel, Oroxylum indicum, Croton oil edema method, Anti-inflammatory activity.
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