Journal of Medicinal Materials, 2017, Vol. 22, No. 5 (pp. 270 - 275)

TRITERPENE GLYCOSIDES ISOLATED FROM

GYMNEMA SYLVESTRE (RETZ.) R. BR. ex SCHULT.

Hoang Minh Chau¹, Pham Ha Thanh Tung^2,3, Oh Won Keun³,

 Nguyen Thi Bich Thu^4,*, Tran Van On², Tran Minh Ngoc⁴

¹Nam Duoc Jsc.; ²Hanoi University of Pharmacy, ³Korea Bioactive Natural Material Bank,

College of Pharmacy; ⁴National Institute of Medicinal Materials, Hanoi, Vietnam

*Corresponding author:  ngbichthu@gmail.com

(Received August, 18^th, 2017)

Summary

Triterpene Glycosides Isolated from Gymnema  sylvestre  (Retz.) R. Br. ex Schult.

From the triterpenoid-rich fraction of Gymnema sylvestre (Retz.) R. Br. Ex Schult., one new compound, 3-O-[β-D-xylopyranosyl(1à6)-β-D-glucopyranosyl(1à6)-β-D-glucopyranosyl] oleanolic acid 28-[β-D-glucopyranosyl(1à6)-β-D-glucopyranosyl]  ester (1), and two known compounds, 3-O-[β-D-xylopyranosyl(1à6)-β-D-glucopyranosyl(1à6)-β-D-glucopyranosyl] oleanolic acid 28-β-D-glucopyranosyl ester (2) and 3-O-[β-D-glucopyranosyl(1à6)-β-D-glucopyranosyl] oleanolic acid 28-[β-D-glucopyranosyl(1à6)-β-D-glucopyranosyl]  ester (3) were isolated. The chemical structure of the new compound was elucidated by the extensive nuclear magnetic resonance (NMR), mass spectrometry (MS) and other spectroscopic techniques; while the structures of the two known compounds were verified by comparing their physicochemical and spectroscopic data to published literature.

Keywords: Gymnema sylvestre, Apocynaceae, Oleanolic acid, Saponin.

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