Journal of Medicinal Materials, 2019, Vol. 24, No. 5 (pp. 297 - 300)
IN VITRO ANTIOXIDANT ACTIVITY AND IN VIVO HEPATOPROTECTIVE EFFECTS OF TOTAL ETHANOLIC EXTRACT FROM FICUS AURICULATA FRUITS
Tran Truong Giang1, Luu Thi Nghia2, Do Thi Hong Tuoi2, Huynh Ngoc Trinh2,*
1Department of Pharmacy, School of Medicine and Pharmacy, Tra Vinh University;
2Department of Pharmacology, Faculty of Pharmacy,
University of Medicine and Pharmacy at Ho Chi Minh City *Corresponding author: hntrinh@ump.edu.vn
(Received September, 09th, 2019)
Summary
In vitro Antioxidant Activity and In vivo Hepatoprotective Effects
of Total Ethanolic Extract from Ficus auriculata Fruits
This study aims at evaluating the in vitro antioxidant activity and the in vivo hepatoprotective effects of total ethanolic extract from Ficus auriculata fruits. Ficus auriculata fruits were extracted with ethanol 90%, 70% and 50% by percolation method. The in vitro antioxidant activity was assessed by reaction with DPPH reagent. The in vivo hepatoprotective effects were investigated in a mouse model of carbon-tetrachloride (CCl4) induced acute liver damage. Ficus auriculata extract (250 mg/kg) or reference drug silymarin (50 mg/kg) were orally administered twice a day for 14 days consecutively prior to liver damage by CCl4. Experimental results showed ethanol 70% extract presented the highest antioxidant activity through DPPH scavenging effect among 3 studied extracts. This extract also exhibited the hepatoprotective effects equivalent to silymarin by preventing hepatic damage induced by CCl4.
Keywords: Antioxidant, Carbon-tetrachloride, DPPH, Ficus auriculata.
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