EFFECTS OF ETHANOLIC LEAF EXTRACT OF MANGIFERA INDICA L. ON BLOOD GLUCOSE LEVEL IN MSG-INDUCED TYPE 2 DIABETIC MICE
Hoang Le Son*, To Ngoc Kim Thanh, Tran Van Minh
International University, Vietnam National University Ho Chi Minh City
(Received August 15h, 2014)
Effect of Ethanolic Leaf Extract of Mangifera indica L. on Blood Glucose Level in MSG-Induced type 2 Diabetic Mice
The aim of this study was to investigate the anti-hyperglycemic property of ethanolic leaf extract of Mangifera indica in monosodium glutamate (MSG)-induced type 2 diabetic mouse model. The results showed that the ethanolic leaf extract of Mangifera indica at a dose of 250 mg/kg body weight significantly reduced blood glucose level up to 25.4% in MSG-induced type 2 diabetic mice after 4 hours of administration, higher than that of negative control (8.83%). Meanwhile, the hypoglycemic effect of the positive control (Metformin) was recorded up to 26.26% after 4 hours of treatment.
Keywords: Mangifera indica, Anti-hyperglycemic, MSG-induced, Mouse model.
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