EFFECTS OF ETHANOLIC LEAF EXTRACT OF MANGIFERA INDICA L. ON BLOOD GLUCOSE LEVEL IN MSG-INDUCED TYPE 2 DIABETIC MICE

Hoang Le Son*, To Ngoc Kim Thanh, Tran Van Minh

International University, Vietnam National University Ho Chi Minh City

^* hlson@hcmiu.edu.vn

(Received August 15^h, 2014)

Summary

Effect of Ethanolic Leaf Extract of Mangifera indica L. on Blood Glucose Level in MSG-Induced type 2 Diabetic Mice

The aim of this study was to investigate the anti-hyperglycemic property of ethanolic leaf extract of Mangifera indica in monosodium glutamate (MSG)-induced type 2 diabetic mouse model. The results showed that the ethanolic leaf extract of Mangifera indica at a dose of 250 mg/kg body weight significantly reduced blood glucose level up to 25.4% in MSG-induced type 2 diabetic mice after 4 hours of administration, higher than that of negative control (8.83%). Meanwhile, the hypoglycemic effect of the positive control (Metformin) was recorded up to 26.26% after 4 hours of treatment.

Keywords: Mangifera indica, Anti-hyperglycemic, MSG-induced, Mouse model.

(Nguồn tin: )