Summary

DPPH Radical Scavenging Activity of a-, b-, and g-Mangostin

and O-Alkylated a-Mangostin Derivatives

The antioxidant activity of α-, b-, and g-mangostin and O-alkylated α-mangostin derivatives were evaluated based on radical scavenging effect of the stable DPPH. The results showed that g-mangostin with three free hydroxyl groups at C-3, C-6 and C-7 had better activity than those of α- and b-mangostin, which have one or two hydroxyl groups, respectively. g-Mangostin exhibited even greater capacity than that of ascorbic acid, the positive control. On the other hand, when the hydroxyls at C-3 and C-6 in α-mangostin were O-alkylated, the activity decreased dramatically. The finding reveals that hydroxyl substituents in the aromatic ring system of the xanthone skeleton may play an important role in antioxidant activity.

Key words: α-Mangostin, b-mangostin, g-mangostin, O-alkylated α-mangostin, DPPH radical scavenging

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