Inhibitive Activity on NF-kB of Triterpene Compounds Isolated from Boehmeria niveaLeaves
A bioassay-guided phytochemical investigation of the methanol extract of the Boehmeria nivea leaves led to the isolation of three pentacyclic triterpenoids. By means of spectroscopic methods including ESI-MS and 1D-NMR, their structures were determined as oleanolic acid (1), ursolic acid (2) and betulinic acid (3). The isolated compounds showed strong NF-kB inhibitory activity with the IC50 values of 13.6, 4.7 and 6.2 mM, respectively.
Keywords: Boehmeria nivea; oleanolic acid; betunilic acid; ursolic acid; NF-kB.
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