Summary

Effect of Sweet Potato (Ipomoea batatas L.) Leaf Extract on Hypoglycaemia, BloodInsulin Secretion, and Key Carbohydrate Metabolic Enzymes in Expermentally Obese and STZ-induced Diabetic Mice

Hypolipidemic, hypoglycaemic effect of the ethyl acetate extract fraction from leaves of sweet potato (Ipomoea batatas (L.) Lam.) (Convolvulaceae) in obese and streptozotocin (STZ) induced type II diabetic mice was demonstrated. When obese-diabetic mice administrated orally daily by ethyl acetate fraction of  1000 mg lyophilized powder/kg for 21 days, we showed that maximum hypoglycaemic (36.77%) and hypolipidemic effects, such as TC (35.18%), TG (29.17%), and LDLc (51.97%) were proven in treated mice compared to the control (untreated mice). The mechanism of hypoglycaemic activity of ethyl acetate extract fraction from leaves of sweet potato indicated that it accelerated hexokinase activity, stimulated  insulin secretion and inhibited gluconeogenesis enzymatic activity (glucose-6-phosphatase).

Keywords: Ipomoea batatas leaf; obese mice; type II diabetes mellitus; hypolipidemic and hypoglycaemic effect.

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