Effects of Vietnamese Ginseng and Polyscias fruticosa on Immunodeficiency Model

Effects of Vietnamese ginseng and Polyscias fruticosa on cyclophosphamide-induced immunodeficiency were studied in mice. Cyclophosphamide at the single dose of 150 mg/kg significantly induced a decrease of white blood cells, neutrophils and an increase of lymphocytes. Besides, cyclophosphamide decreased spleen and thymus weights and inhibited phagocytic activity of macrophages. Vietnamese ginseng extract (100-200 mg/kg) and Polyscias fruticosa leaves extract (50-100 mg/kg) ameliorated cyclophosphamide-induced decrease in spleen and thymus weights. These extracts as well as zymosan-A, a positive control also increased phagocytic activity of macrophages in both normal mice and immunodeficiency mice. However, the extracts did not produce any significant effect on cyclophosphamide-induced hematological changes.

Key words: Vietnamese ginseng, Polyscias fruticosa, cyclophosphamide, phagocytic activity, hematological changes.

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