Journal of Medicinal Materials, 2023, Vol. 28, No. 4 (pp. 240 - 244)
ANTI-INFLAMMATORY EFFECTS OF ETHANOL EXTRACT
FROM HOMALOMENA PIERREANA RHIZOME
Nguyen Thi Thu Huong*, Nguyen Thi Ngọc Yen, Tran Thi Duoc
Faculty of Pharmacy, Hong Bang International University
*Corresponding author: huongsam@hotmail.com
(Received July 28th, 2023)
Summary
Anti-Inflammatory Effects of Ethanol Extract from Homalomena pierreana Rhizome
Homalomena has been used in traditional medicine as pain relief in rheumatic diseases. Homalomena pierreana (HP) is a rare species of the Araceae family found in Vietnam. This study aimed to investigate the anti-inflammatory effects of ethanol extract from HP H. pierreana rhizome by using lipopolysaccharide (LPS)-induced nitric oxide (NO) production in murine macrophage cell line RAW 264.7 and a carrageenan-induced paw edema test in mice. The results revealed that HP extract inhibited NO production (up to 68.7%) at 100 μg/mL in a concentration-dependent manner in LPS-stimulated RAW 264.7 macrophages. The NO production inhibitory activity of HP extract was equivalent to a positive control, dexamethasone, at the concentration of 50 μg/mL. Furthermore, the extract at doses of 390 mg/kg and 780 mg/kg (equivalent to 1.25 and 2.5 g raw materials) attenuated 25.9% to 35.6% of paw inflammation after 3 hours of carrageenan injection as compared to control. In conclusion, this is a first report to determine the anti-inflammatory effects of ethanol extract from HP rhizome. The follow-up studies should aim at elucidating the anti-inflammatory mechanisms of HP rhizome to achieve beneficial effects of this plant for medicine usages.
Keywords: Homalomena pierreana, Lipopolysaccharide-induced NO production, RAW 264.7 macrophages, Carrageenan-induced mouse paw edema.
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