Journal of Medicinal Materials, 2021, Vol. 26, No. 1+2 (pp. 60 - 65)

ANTI-MICROBIAL DIKETOPIPERAZINES

FROM THE SEA URCHIN-DERIVED PENICILLIUM SP. M408

Cao Duc Tuan^1,*, Vu Van Nam², Nguyen Mai Anh², Hoang Thi Hong Lien³, Dao Minh Dong⁴, Young-Ho Kim⁵, Le Thi Hong Minh², Pham Van Cuong², Doan Thi Mai Huong²,

Nguyen Van Hung^1,*

¹Hai Phong University of Medicine and Pharmacy, Haiphong, Vietnam;

²Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam;

³Buon Ma Thuot University, Daklak, Vietnam;

⁴Bach Long Vy National Marine Protected Area, Haiphong, Vietnam;

⁵College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea

*Corresponding author: nvhung@hpmu.edu.vn; cdtuan@hpmu.edu.vn

(Received December 16^th, 2020)

Summary

Anti-Microbial Diketopiperazines from the Sea Urchin-Derived Penicillium sp. M408

Marine fungi are valuable sources of biologically active metabolites. During the course of our screening program, the ethyl acetate extract of a marine-derived fungus strain (Penicillium sp. M408) exhibited anti-microbial activities against both gram positive bacteria and a yeast strain. This paper reported the isolation, structure elucidation, and anti-microbial activities of six diketopiperazines, cyclo(L-Pro-L-Val) (1), cyclo(L-Pro-L-Leu) (2), cyclo(L-Pro-L-Phe) (3), cyclo(L-Pro-L-Trp) (4), tryprostatin B (5), and 12,13-dihydroxy-fumitremorgin C (6) from the fungus strain M408 associated with Echinometra lucunter (Linnaeus, 1758). Only compounds 5 and 6 exhibited anti-microbial activities against tested microbial pathogens.

Keywords: Anti-microbial, Diketopiperazine, Penicillium, Vietnam East Sea.

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