Journal of Medicinal Materials, 2018, Vol. 23, No. 5 (pp. 301 - 308)

ANTI-DEMENTIA EFFECTS OF ILEX KUDINGCHA LEAVES

ON OLFACTORY BULBECTOMY-INDUCED

MEMORY IMPAIRMENT IN MICE

Pham Thi Nguyet Hang^1,*, Phi Thi Xuyen¹, Le Thi Xoan¹, Nguyen Minh Khoi¹, Nguyen Thi Lap²,

Kinzo Matsumoto³, Masamitsu Yamaguchi⁴, William R. Folk⁵

1. National Institute of Medicinal Materials, Hanoi, Vietnam; ²Hanoi University of Pharmacy, Vietnam; ³Institute of Natural Medicine, University of Toyama, Japan; ⁴Kyoto Institute of Technology, Japan; ⁵University of Missouri, USA

*Corresponding author: pnhang2004@yahoo.com

(Received April, 11^th, 2017)

Summary

Anti-dementia Effects of Ilex kudingcha Leaves in Olfactory Bulbectomy-Induced Memory Impairment in Mice

Ilex kudingcha (IK) known as bitter tea has been traditionally used to resolve toxin, antibacterial, alleviating thirst, coughing, itchy eyes, red eyes, especially to improve mental focus and memory. The present study was conducted to investigate the anti-dementia effect of IK using olfactory bulbectomized (OBX) mice. OBX mice were daily treated with IK extract (540 mg/kg) or reference drug, tacrine (2.5 mg/kg) one week before and continuously for 3 days after the OBX surgery. The object recognition test, modified Y maze test and fear conditioning test were employed to analyze non-spatial short-term, spatial short-term and long-term memories of the mice, respectively. OBX mice had impaired non-spatial short-term, spatial short-term and long-term memories. Administration of IK extract and tacrine attenuated these OBX-induced cognitive deficits in mice. The effects of IK and tacrine on spatial short-term memory impairment were reversed by scopolamine, a muscarinic receptor antagonist. These results indicated that IK extract improves short-term and long-term memory disturbances in OBX mice and that muscarinic receptor may play a role on these actions.

Keywords: Ilex kudingcha, Ilex latifolia, Anti-dementia, Olfactory bulbectomy, memory deficits.

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