Journal of Medicinal Materials, 2018, Vol. 23, No. 5 (pp. 301 - 308)
ANTI-DEMENTIA EFFECTS OF ILEX KUDINGCHA LEAVES
ON OLFACTORY BULBECTOMY-INDUCED
MEMORY IMPAIRMENT IN MICE
Pham Thi Nguyet Hang1,*, Phi Thi Xuyen1, Le Thi Xoan1, Nguyen Minh Khoi1, Nguyen Thi Lap2,
Kinzo Matsumoto3, Masamitsu Yamaguchi4, William R. Folk5
*Corresponding author: firstname.lastname@example.org
(Received April, 11th, 2017)
Anti-dementia Effects of Ilex kudingcha Leaves in Olfactory Bulbectomy-Induced Memory Impairment in Mice
Ilex kudingcha (IK) known as bitter tea has been traditionally used to resolve toxin, antibacterial, alleviating thirst, coughing, itchy eyes, red eyes, especially to improve mental focus and memory. The present study was conducted to investigate the anti-dementia effect of IK using olfactory bulbectomized (OBX) mice. OBX mice were daily treated with IK extract (540 mg/kg) or reference drug, tacrine (2.5 mg/kg) one week before and continuously for 3 days after the OBX surgery. The object recognition test, modified Y maze test and fear conditioning test were employed to analyze non-spatial short-term, spatial short-term and long-term memories of the mice, respectively. OBX mice had impaired non-spatial short-term, spatial short-term and long-term memories. Administration of IK extract and tacrine attenuated these OBX-induced cognitive deficits in mice. The effects of IK and tacrine on spatial short-term memory impairment were reversed by scopolamine, a muscarinic receptor antagonist. These results indicated that IK extract improves short-term and long-term memory disturbances in OBX mice and that muscarinic receptor may play a role on these actions.
Keywords: Ilex kudingcha, Ilex latifolia, Anti-dementia, Olfactory bulbectomy, memory deficits.
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