Journal of Medicinal Materials, 2019, Vol. 24, No. 5 (pp. 286 - 292)
ANTI-FATIGUE, ANTI-HYPERGLYCEMIC AND ANTI-INFLAMMATORY EFFECTS OF MORINGA OLEIFERA STEM BARKS
Nguyen Thi Thu Huong*, Mai Thanh Chung, Ha Quang Thanh, Nguyen Hoang Minh,
Chung Thi My Duyen, Dao Tran Mong, Nguyen Mai Truc Tien, Tran My Tien
Research Center of Ginseng and Medicinal Materials in Ho Chi Minh City -
National Institute of Medicinal Materials, Hanoi, Vietnam
*Corresponding author: firstname.lastname@example.org
(Received August, 28th, 2019)
Anti-fatigue, Anti-hyperglycemic and Anti-inflammatory Effects of Moringa oleifera Stem Barks
The 45% ethanolic extract from Moringa oleifera stem barks (MOB-E) was used for the study. Brekhman’s mouse swimming test was applied to investigate the anti-fatigue effect. The oral glucose tolerance test and streptozotocin-induced diabetic model were used for study on anti-hyperglycemic effect. The carrageenan-induced paw edema and myeloperoxidase (MPO) assay were applied for study on anti-inflammatory effects. The results revealed that MOB-E at the oral doses of 0.44 g/kg and 0.88 g/kg (equivalent to 5 - 10 g of raw materials) expressed the anti-fatigue effect after 14-day administration. MOB-E at the dose of 0.88 g/kg after 7-day administration showed the hypoglycemic effect which was as the same as glibenclamide. The extract reduced mouse paw edema and MPO activity when compared with the untreated groups, indicating anti-inflammatory effects.
Keywords: Moringa oleifera stem barks, Anti-fatigue effect, Anti-hyperglycemic effect, Anti-inflammatory effects.
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