Ấn phẩm

Antimicrobial Compounds Produced by the Marine Actinomycete Streptomyces sp. G668 (Journal of Medicinal Materials, 2022, Vol. 27, No. 2)

Journal of Medicinal Materials, 2022, Vol. 27, No. 2 (pp. 72 - 76)

 

ANTIMICROBIAL COMPOUNDS PRODUCED

BY THE MARINE ACTINOMYCETE STREPTOMYCES SP. G668

Do Thi Quynh1,2, Nguyen Thuy Linh1, Le Thi Hong Minh1, Nguyen Mai Anh1,

Doan Thi Mai Huong1,2,*, Pham Van Cuong 1,2,*

1Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST),

Hanoi, Vietnam;

2Graduate University of Science and Technology, Vietnam Academy of Science and Technology,

Hanoi, Vietnam

*Corresponding author: huongdm@imbc.vast.vn; phamvc@imbc.vast.vn

(Received April 06th, 2022)

Summary

Antimicrobial Compounds Produced by the Marine Actinomycete Streptomyces sp. G668

From the ethyl acetate extract of the Streptomyces sp. G668 strain, seven compounds were isolated: 9H-pyrido[3,4-b]indole (1), L-tryptophan (2), indole-3-carboxylic acid (3), 3-indolylacetic acid (4), cyclo-(Pro-Ala) (5), uracil (6), thymine (7). Their structures were elucidated by nuclear magnetic resonance spectroscopy (NMR), mass spectroscopy (MS) and comparison with the reference data. Compound 1 exhibited moderate antibacterial activity against Escherichia coli ATCC25922 and compound 5 strongly inhibited Candida albicans ATCC10231.

Keywords: Marine actinomycetes, Streptomyces, Alkaloid, Indole, Cyclodipeptide.

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