Journal of Medicinal Materials, 2018, Vol. 23, No. 3 (pp. 152 - 157)

CHEMICAL COMPOSITION OF AMALOCALYX MICROLOBUS (SPIRE) PIERRE - (APOCYNACEAE) COLLECTED IN SON LA, VIETNAM

Nguyen Hoang Tuan^1,*, Bui Hong Cuong¹, Vi Thi Thoi²,  Pham Ngoc Khanh^1,3

¹Hanoi University of Pharmacy, Hanoi, Vietnam;

²Son La Medical College, Vietnam;

³Institute of Natural products Chemistry, Vietnam Academy of Science and Technology, Vietnam

*Corresponding author: tuandl50@yahoo.com

(Received March, 30^th, 2018)

Summary

Chemical Composition of Amalocalyx microlobus (Spire) Pierre - (Apocynaceae)

Collected in Son La Province, Vietnam

From an EtOAc-soluble fraction of the methanol extract from the leaves of Amalocalyx microlobus (Spire) Pierre (Apocynaceae), local name Sơn Đôn, collected in Son La, Vietnam, five compounds including: Luteolin (a flavonoid) (1), luteolin-4'-O-β-glucopyranoside (a flavonoid glycoside) (2), amalogenin A (a pregnen-type sterol) (3), β-sitosterol (4) and daucosterol (5) have been isolated. Their chemical structures were established through spectroscopic evidences including 1D, 2D-NMR and MS data. This is the first report on the chemical composition of the species Amalocalyx microlobus in Vietnam.

Keywords: Amalocalyx microlobus, Luteolin, Amalogenin A, Daucosterol, β-sitosterol, Sơn Đôn.

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