Ấn phẩm

Chemical Constituents and Cytotoxic Activity of the n-Hexane Extract from the Aerial Parts of Curcuma zedoaroides Chaveer. & Tanee (Journal of Medicinal Materials, 2024, Vol. 29, No. 2)

Journal of Medicinal Materials, 2024, Vol. 29, No. 2 (pp.70 - 76)

CHEMICAL CONSTITUENTS AND CYTOTOXIC ACTIVITY

OF THE n-HEXANE EXTRACT FROM THE AERIAL PARTS

OF CURCUMA ZEDOAROIDES CHAVEER. & TANEE

Nguyen Thi Thu¹, Tran Trung Hieu², Nguyen Manh Khoa¹, Hoang Thi Dieu Huong¹,

Le Hong Van Anh³, Hoang Van Trung⁴, Nguyen Hoang Tuan^3,*, Do Thi Ha^1,*

¹National Institute of Medicinal Materials (NIMM), Hanoi 11022, Vietnam;

²Department of Chemistry, Vinh University, Nghean Province, Vietnam;

³Faculty of Pharmacognosy and Traditional Medicine, Hanoi University of Pharmacy, Hanoi, Vietnam;

⁴School of Chemistry, Biology and Environment, Vinh University, Nghean Province, Vietnam

*Corresponding authors: tuandl50@yahoo.com and hado.nimms@gmail.com

(Received March 12^th, 2024)

Summary

Chemical Constituents and Cytotoxic Activity of the n-Hexane Extract from the Aerial Parts

of Curcuma zedoaroides Chaveer. & Tanee

Curcuma zedoaroides Chaveer. & Tanee, belonging to the gennus Curcuma (Zingiberaceae), is a newly discovered species in Vietnam. In the present study, the chemical constituents and the in vitro cytotoxic activity of the n-hexane extract from the C. zedoaroides aerial parts were reported for the first time. The n-hexane extract showed the most potent cytotoxic effect among all tested extracts on seven human cancer cell lines (A549, MCF-7, HepG2, HT-29, HL-60, K562, and MDA-MB-231), with IC₅₀ values ranging from 49.76 - 86.30 µg/mL using sulforhodamine B and MTT methods. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that a total of 10 components were identified from the n-hexane extract. Among these, curdione (a major compound, accounting for 41.12% of total content) was isolated from C. zedoaroides for the first time. Its structure was determined by 1D-, 2D-NMR, and MS spectroscopic techniques and compared with the previous publication. This study provides significant data on the chemical constituents and cytotoxic effects of the n-hexane extract of C. zedoaroides aerial parts. These findings suggest that C. zedoaroides extract can be exploited for its potential cytotoxic effect.