Journal of Medicinal Materials, 2019, Vol. 24, No. 3 (pp.168 - 174)
EFFECTS OF AQUEOUS AND ETHANOL EXTRACTS FROM
VERNONIA AMYGDALINA LEAVES ON BLOOD GLUCOSE LEVEL
AND OXIDATIVE STRESS IN
STREPTOZOTOCIN-INDUCED DIABETIC MICE
Dao Tran Mong, Nguyen Thi Thu Huong*
Research Center of Ginseng and Medicinal Materials,
National Institute of Medicinal Materials, Ho Chi Minh City, Vietnam
*Corresponding author: huongsam@hotmail.com
(Received April, 12th, 2019)
Summary
Effects of Aqueous and Ethanol Extracts from Vernonia amygdalina Leaves on Blood Glucose Level and Oxidative Stress in Streptozotocin-Induced Diabetic Mice
Vernonia amygdalina Del. has been extensively used as a traditional medicine in Southeast Asian countries for centuries, especially in Africa and India. In recent years, V. amygdalina has attracted the attention of researchers because the compounds in the plant bring many health benefits such as support for treatment of diseases: diabetes, anti-allergy, anti-cancer, antioxidants, liver protection, and prevention of cardiovascular diseases via stabilizing blood lipids. The study investigated effects of aqueous and 45% ethanol V. amygdalina leaf extracts (VAA and VAE) on blood glucose levels in the oral glucose tolerance test (OGTT) and in streptozotocin - induced diabetic mice. The results showed that VAA and VAE at respective doses of 0.64 g/kg, 1.28 g/kg and 0.85 g/kg, 1.7 g/kg had modulatory effect on prosprandial blood glucose in OGTT and antihyperglycemic effect by decreasing blood glucose levels in streptozotocin - induced diabetic mice. Moreover, VAA and VAE at respective doses of 0.64 g/kg, 1.28 g/kg and 0.85 g/kg, 1.7 g/kg also had the protective effect against oxidative stress-induced tissue damage in diabetic mice by decreasing malondialdehyde (MDA) in mouse liver and kidney.
Keywords: Vernonia amygdalina leaves, Oral glucose tolerance test, Streptozotocin - induced diabetic mice, Malondialdehyde (MDA).
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