Journal of Medicinal Materials, 2023, Vol. 28, No. 4 (pp. 249 - 255)
EVALUATION OF THE SKIN IRRITATION
AND ANTI-INFLAMMATORY ACTIVITY OF A GEL CONTAINING
PERILLA FRUTESCENS EXTRACT AND GLYCYRRHIZA URALENSIS EXTRACT
Huynh Thi My Duyen *, Le Thi Minh Ngoc, Tran Thi Mong Tuyen, Duong Tuyet Ngan,
Pham Thi Ngoc Linh, Nguyen Nhu Huynh, Nguyen Nhu Y, Mai Le Gia Ngan,
Nguyen Ngoc Nguyen Trang, Lam Vi Trang
Can Tho University of Medicine and Pharmacy
*Corresponding author: email@example.com
(Received June 02nd, 2023)
Evaluation of the Skin Irritation and Anti-Inflammatory Activity
of a Gel Containing Perilla frutescens Extract and Glycyrrhiza uralensis Extract
The study prepared the herbal gel with 0.75% of carbopol 940, 0.85% of Perilla frutescens (PF) extract, 0.7% of Glycyrrhiza uralensis Fisch (GU) extract. and other excipients. In vitro testing showed that the product was non-irritating and safe; the anti-inflammatory activity of the gel had an IC50 value of 303.33 µg/mL. The total polyphenol content and flavonoid content were 2.9 mg GAE/g and 1.82 mg QCE/g, respectively. The research prepared and evaluated the skin irritation of the gel by the HET-CAM (Hen's EggTest on the Chorioallantoic Membrane) method. At the same time, the study assessed the anti-inflammatory activity and quantified polyphenols and flavonoids in the finished gel.
Keywords: Perilla frutescens, Glycyrrhiza uralensis, Gel, Anti-inflammatory, HET-CAM, Irritation.
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