Journal of Medicinal Materials, 2023, Vol. 28, No. 4 (pp. 249 - 255)

EVALUATION OF THE SKIN IRRITATION

AND ANTI-INFLAMMATORY ACTIVITY OF A GEL CONTAINING

PERILLA FRUTESCENS EXTRACT AND GLYCYRRHIZA URALENSIS EXTRACT

Huynh Thi My Duyen *, Le Thi Minh Ngoc, Tran Thi Mong Tuyen, Duong Tuyet Ngan,

Pham Thi Ngoc Linh, Nguyen Nhu Huynh, Nguyen Nhu Y, Mai Le Gia Ngan,

Nguyen Ngoc Nguyen Trang, Lam Vi Trang

Can Tho University of Medicine and Pharmacy

*Corresponding author: htmduyen@ctump.edu.vn

(Received June 02^nd, 2023)

Summary

Evaluation of the Skin Irritation and Anti-Inflammatory Activity

of a Gel Containing Perilla frutescens Extract and Glycyrrhiza uralensis Extract

The study prepared the herbal gel with 0.75% of carbopol 940, 0.85% of Perilla frutescens (PF) extract, 0.7% of Glycyrrhiza uralensis Fisch (GU) extract. and other excipients. In vitro testing showed that the product was non-irritating and safe; the anti-inflammatory activity of the gel had an IC₅₀ value of 303.33 µg/mL. The total polyphenol content and flavonoid content were 2.9 mg GAE/g and 1.82 mg QCE/g, respectively. The research prepared and evaluated the skin irritation of the gel by the HET-CAM (Hen's EggTest on the Chorioallantoic Membrane) method. At the same time, the study assessed the anti-inflammatory activity and quantified polyphenols and flavonoids in the finished gel.

Keywords: Perilla frutescens, Glycyrrhiza uralensis, Gel, Anti-inflammatory, HET-CAM, Irritation.

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