Journal of Medicinal Materials, 2021, Vol. 26, No. 1+2 (pp. 107 - 113)
HEPATOPROTECTIVE EFFECT OF MUNTINGIA CALABURA
LEAF EXTRACTS ON PARACETAMOL-INDUCED HEPATOTOXICITY
Nguyen Viet Quang1, Ha Quang Thanh2, Nguyen Hoang Minh2, Nguyen Thi Thu Huong2,*
1Faculty of Pharmacy and Nurse, Tay Do University;
2Research Center of Ginseng and Medicinal Materials in Ho Chi Minh City -
National Institute of Medicinal Materials, Hanoi, Vietnam
*Corresponding author: huongsam@hotmail.com
(Received November 10th, 2020)
Summary
Hepatoprotective Effect of Muntingia calabura Leaf Extracts on Paracetamol-Induced Hepatotoxicity
The study investigated the hepatoprotective activity of the leaf extracts of Muntingia calabura using a paracetamol-induced hepatotoxicity mouse model. The results revealed that paracetamol (APAP) orally administered at dose of 250 mg/kg for 15 days induced an increase in hepatic malondialdehyde (MDA) content, plasma levels of aspartate aminotransferase (AST), and alanine aminotransferase (ALT), and significantly decreased hepatic glutathione (GSH) content in mice. Oral administration of 45% ethanol extract of M. calabura (EEMC) and water extract of M. calabura (WEMC) at the doses equivalent to 2.5 g and 5 g raw materials/kg, as well as silymarin (0.1 g/kg) decreased plasma AST and ALT concentrations in APAP-intoxicated mice. Moreover, EEMC and WEMC also improved the oxidative stress status in mouse liver through effective reduction of hepatic MDA levels and increasing of hepatic GSH levels. This study suggests that M. calabura leaves may be represented as a potential hepatoprotective candidate.
Keywords: Muntingia calabura, Paracetamol-induced hepatotoxicity mouse model, Hepatoprotective effects.
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