Journal of Medicinal Materials, 2019, Vol. 24, No. 5 (pp.301 - 308)
HYPOGLYCEMIC EFFECT AND ACUTE TOXICITY
OF THE POLYHERBAL FORMULATION (DANGT)
IN STREPTOZOCIN-INDUCED DIABETIC TYPE 2 MICE
Nguyen Thi Xuan Thu1, Dang Duc Long2,*, Giang Thi Kim Lien3
1Faculty of Chemistry, Danang University of Technology - The University of Danang;
2VN-UK Institute for Research and Executive Education - The University of Danang;
3The University of Danang *Corresponding author: long.dang@vnuk.edu.vn
(Received September, 19th, 2019)
Summary
Hypoglycemic Effect and Acute Toxicity of the Polyherbal Formulation (DANGT)
in Streptozocin-Induced Diabetic Type 2 Mice
This study aims to evaluate a resonant antidiabetic capability of a polyherbal formulation in Streptozotocin-induced diabetic mice. The polyherbal formulation (DANGT) contains the 70% alcohol extracts of Vernonia amygdalina, Ampelosis cantoniensis, Stevia rebaudiana, Gynostemma pentaphyllum and Gymnema sylvestre in the ratio of 1:1:1:1:1 by weight. At the dose 350 mg/kg, DANGT formulation demonstrated a better hypoglycemic effect as compared to the individual extracts. Administration of 500 mg/kg and 1000 mg/kg doses of the formulation significantly decreased the level of blood glucose in diabetic mice and had the effect equal to that of the commercial drug Piogliteâ at the dose of 20 mg/kg. DANGT formulation-treated mice showed significant decreases in cholesterol and triglyceride levels and reached the levels in normal mice. The herbal formulation and Piogliteâ-treated diabetic mice showed a significant increase in liver glycogen levels (75.62% and 77.27%, resp.) when compared to the diabetic control group. The acute toxicity studies of the polyherbal formulation did not show any toxic symptoms at doses up to 38.4 g/kg over 7 days.
Keywords: Hypoglycemic, DANGT Extract, Cholesterol, Ttriglyceride, Glycogen, Acute Toxicity.
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