Ấn phẩm

In vitro α-Glucosidase Inhibitory Activity and In vivo Hypoglycemic Effect of Twig Extracts from Morus alba (Journal of Medicinal Materials, 2020, Vol. 25, No. 5)

Journal of Medicinal Materials, 2020, Vol. 25, No. 5 (pp. 307 - 311)

 

IN VITRO α-GLUCOSIDASE INHIBITORY ACTIVITY AND IN VIVO HYPOGLYCEMIC EFFECT OF TWIG EXTRACTS FROM MORUS ALBA

Nguyen Ngoc Qui1, Huynh Ngoc Trinh2,*, Nguyen Thi Mong Thi3, Huynh Ngoc Thuy3

1Department of Pharmacy, Binh Duong Medical College, Vietnam;

2Department of Pharmacology, Faculty of Pharmacy, University of Medicine and Pharmacy at

Ho Chi Minh City, Vietnam; 3Department of Medicinal Materials, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam

*Corresponding author: hntrinh@ump.edu.vn

(Received September, 07th, 2020)

Summary

In vitro α-Glucosidase Inhibitory Activity and In vivo Hypoglycemic Effect of Twig Extracts from Morus alba

The in vitro α-glucosidase inhibitory activities of twig extracts of Morus alba samples collected in Bao Loc city, Lam Dong province from January to December (M1-M12) have been investigated. All of extracts showed in vitro α-glucosidase inhibitory effects. Of these, samples collected in December and January were the most active ones, with IC50 values of 18.851 µg/ml and 26.445 µg/ml, respectively. In vivo oral sucrose tolerance test in mice showed the serum glucose peaks of groups treated with these extracts at the doses of 200 mg/kg and 400 mg/kg were significantly lowered than that of the normal control group and comparable to that of the positive control group (acarbose 10 mg/kg). Hence, the M. alba twigs harvested in January and December in Bao Loc city, Lam Dong province seem to be potential materials in postprandial blood glucose regulation in diabetic patients.

Keywords: Morus alba, α-glucosidase inhibitors, Hypoglycemic, Twig extracts.

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