Journal of Medicinal Materials, 2021, Vol. 26, No. 1+2 (pp. 40 - 46)
METABOLITES FROM THE NUDIBRANCH DENDRODORIS FUMATA
AND THEIR ANTI-MICROBIAL ACTIVITY
Pham Thi Mai Huong1,2, Ha Van Oanh3, Do Thi Thao2,4, Nguyen Phuong Thảo1,*
Nguyen Xuan Cuong1, Nguyen Hoai Nam1, Nguyen Van Thanh1,2
1Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Vietnam;
2Graduate University of Science and Technology, VAST, Hanoi, Vietnam;
3Hanoi University of Pharmacy, Hanoi, Vietnam;
4Institute of Biotechnology, VAST, Hanoi, Vietnam
*Corresponding author: firstname.lastname@example.org
(Received March 10th, 2021)
Metabolites from the Nudibranch Dendrodoris fumata and their Anti-Microbial Activity
Chemical examination of the nudibranch mollusk Dendrodoris fumata resulted in the isolation and characterization of six steroids and two terpenoids from the methanol extract. Their structures were elucidated as 5α,6α-epoxy-3β,7α-dihydroxycholest-8(14)-ene (1), cholest-7-ene-3β,5α,6β-triol (2), 3β-hydroxycholesta-5,8-dien-7-one (3), cholest-7-ene-6-one-3β,5α,9α-triol (4), 5α,8α-epidioxy-cholest-6-en-3β-ol (5), 5α,8α-epidioxycholesta-6,9(11)dien-3β-ol (6), and 3α,6β-dihydroxy-1,1,5-trimethyl-8-oxo-1,2,3,4,5,6-hexahydrobenzofuran (7), and amijiol-7,10-diacetate (8), using 1D and 2D NMR experiments and comparison with reported data. The anti-microbial activity of the isolated metabolites against a selected panel of the Gram-positive and Gram-negative bacteria, as well as a set of yeast molds, were also determined.
Keywords: Dendrodoris fumata; Dendrodorididae; Steroid; Terpenoid; Anti-microbial activity.
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