Journal of Medicinal Materials, 2021, Vol. 26, No. 1+2 (pp. 40 - 46)

METABOLITES FROM THE NUDIBRANCH DENDRODORIS FUMATA

AND THEIR ANTI-MICROBIAL ACTIVITY

Pham Thi Mai Huong^1,2, Ha Van Oanh³, Do Thi Thao^2,4, Nguyen Phuong Thảo^1,*

Nguyen Xuan Cuong¹, Nguyen Hoai Nam¹, Nguyen Van Thanh^1,2

¹Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Vietnam;

²Graduate University of Science and Technology, VAST, Hanoi, Vietnam;

³Hanoi University of Pharmacy, Hanoi, Vietnam;

⁴Institute of Biotechnology, VAST, Hanoi, Vietnam

*Corresponding author: thaonp@imbc.vast.vn

(Received March 10^th, 2021)

Summary

Metabolites from the Nudibranch Dendrodoris fumata and their Anti-Microbial Activity

Chemical examination of the nudibranch mollusk Dendrodoris fumata resulted in the isolation and characterization of six steroids and two terpenoids from the methanol extract. Their structures were elucidated as 5α,6α-epoxy-3β,7α-dihydroxycholest-8(14)-ene (1), cholest-7-ene-3β,5α,6β-triol (2), 3β-hydroxycholesta-5,8-dien-7-one (3), cholest-7-ene-6-one-3β,5α,9α-triol (4), 5α,8α-epidioxy-cholest-6-en-3β-ol (5), 5α,8α-epidioxycholesta-6,9(11)dien-3β-ol (6), and 3α,6β-dihydroxy-1,1,5-trimethyl-8-oxo-1,2,3,4,5,6-hexahydrobenzofuran (7), and amijiol-7,10-diacetate (8), using 1D and 2D NMR experiments and comparison with reported data. The anti-microbial activity of the isolated metabolites against a selected panel of the Gram-positive and Gram-negative bacteria, as well as a set of yeast molds, were also determined.

Keywords: Dendrodoris fumata; Dendrodorididae; Steroid; Terpenoid; Anti-microbial activity.

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