Journal of Medicinal Materials, 2021, Vol. 26, No. 3 (pp. 143 - 148)
PHENOLIC METABOLITES FROM THE LEAVES AND STEMS OF DIOSCOREA BULBIFERA WITH ANTI-INFLAMMATORY ACTIVITY
Nguyen Thi Thanh Ngan1, Nguyen Huy Hoang1, Nguyen Thu Hien1, Nguyen Ngoc Lan1,
Nguyen Van Tung1, Pham Thi Mai Huong2, Tran Hong Quang2,*
1 Institute of Genome Research, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
2 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
*Corresponding author: firstname.lastname@example.org
(Received April 27th, 2021)
Phenolic Metabolites from the Leaves and Stems of Dioscorea bulbifera with Anti-Inflammatory Activity
Phytochemical investigation of the leaves and stems of Dioscorea bulbifera resulted in isolation of seven phenolic compounds, including epicatechin (1), epigallocatechin (2), quercetin 3-neohesperidoside (3), benzyl glucopyranoside (4), prunasin (5), phenethyl glucoside (6), and syringaresinol (7). Their chemical structures (1 - 7) were elucidated by spectroscopic evidence, including 1D and 2D NMR and mass spectra in comparison with the literature data. In addition, compounds 1-3, 5, and 7 inhibited nitric oxide (NO) production in LPS-stimulated BV2 microglial cells, with IC50 values ranging from 17.2 to 45.0 mM.
Keywords: Dioscorea bulbifera, Dioscoreaceae, Phenolic, Anti-inflammatory.
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