Journal of Medicinal Materials, 2019, Vol. 24, No. 3 (pp. 180 - 186)
STUDY ON THE ANTIDIABETIC EFFECT OF
MIMOSA PUDICA LINN. LEAF WATER EXTRACT
Nguyen Thi Huyen1, Pham Thi Lan2, Dong Thi Nham1, Dang Kim Thu1, Bui Thanh Tung1,*
1School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam;
2Faculty of Pharmacy, Hanoi University of Business and Technology, Vietnam
*Corresponding author: tungasia82@gmail.com
(Received April, 21st, 2019)
Summary
Study on the Antidiabetic Effect of Mimosa pudica Linn. Leaf Water Extract
Traditional medicine uses Mimosa pudica for supporting the treatment of diabetes. This study was conducted to evaluate the antioxidant effect, α-glucosidase inhibitory activity and anti-hyperglycemic effect of Mimosa pudica leaf (MPL) water extract. Mimosa pudica leaves were extracted by boiling with distilled water for 1 hour, repeating three times. The extract was evaluated the antioxidant activity by scavenging DPPH free radicals, α-glucosidase inhibitory activity in vitro and anti-hyperglycemic effect in vivo on streptozotocin induced diabetic mices (120 mg/kg b.w. i.p). Our results showed that MPL water extract had moderate antioxidant effect with IC50 values of 6.32 mg/mL, strong α-glucosidase inhibitory activity with IC50 values of 3.09 µg/mL. In addition, MPL water extract also showed strong anti-hyperglycemic effect on diabetic mice. Our data showed that Mimosa pudica leaves water extract has the potential antidiabetic effect.
Keywords: Mimosa pudica Linn., Leaf, Streptozotocin, Diabetes, DPPH, α-Glucosidase inhibitory activity.
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