Tạp chí

Nghiên cứu tác dụng tăng cường miễn dịch của nấm linh chi đỏ trên thực nghiệm gây suy giảm miễn dịch bằng cyclophosphamid (Tạp chí Dược liệu, tập 16, số 1+2/2011)

Study on Immunostimulating Effects of Ganoderma lucidum on Cyclophosphamid-Induced Immunosuppressive Model

Immunostimulating effects of Ganoderma lucidum cultivated in Vietnam were studied on cyclophosphamide-induced immunosuppressive mice. The ethanol extract, aqueous extract and crude polysaccharide were extracted from Ganoderma lucidum. Cyclophosphamide (150 mg/kg, intraperitoneal injection) increased the percentage of neutrophils and decreased white blood cells; percentage of lymphocytes; the weights of liver, spleen, thymus; phagocytic index. The results revealed a strong impairment of the cellular response (the delayed type hypersensitivity reaction) in cyclophosphamide-treated mice. The ethanol extract, aqueous extract and crude polysaccharide increased significantly white blood cells and the weights of liver, spleen, thymus. Crude polysaccharide increased phagocytic index; restored the impairment of the cellular response and the changes in percentage of neutrophils, lymphocytes in cyclophosphamide-treated mice. The ethanol extract increased phagocytic index in both naive mice and cyclophosphamide-treated mice. The results revealed that Ganoderma lucidum cultivated in Vietnam has immunostimulating effect on cyclophosphamide-induced immunosuppressive model.