Journal of Medicinal Materials, 2017, Vol. 22, No. 3 (pp. 166-172)
PROTECTIVE EFFECT OF PROCESSED VIETNAMESE GINSENG AGAINST PARACETAMOL-INDUCED HEPATOTOXICITY IN MICE
Danh My Thanh Ngan1, Nguyen Minh Duc2, Nguyen Ngoc Khoi3,*
1School of Medicine, VietNam National University Ho Chi Minh City, Vietnam
2School of Pharmacy, Ton Duc Thang University, Vietnam
3School of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam
*Corresponding author: nnkhoi@yahoo.com
(Received February, 20th, 2017)
Summary
Protective Effect of Processed Vietnamese Ginseng Against Paracetamol-Induced Hepatotoxicity in Mice
Paracetamol (APAP) is widely used as an analgesic and antipyretic drug, which can cause hepatic injury when given in high doses. The objective of the present study was to study and compare the possible effect of Vietnamese Ginseng (VG) and Processed Vietnamese Ginseng (PVG) against APAP-induced hepatotoxicity in mice. In this study, powdered Vietnamese ginseng (VG) was steamed in 12 h at 120°C. 50 mice were divided into 5 equal groups (n = 10): The physiological group, the VG-administerted group (50 mg/kg), the PVG-administerted group (50 mg/kg), the silymarin-administerted group (100 mg/kg). The VG, PVG and silymarin were supplemented as protection for 14 consecutive days prior to single oral dose of APAP (200 mg/kg). After APAP administration 18 h, the mice were sacrificed. Liver injuries were assessed by blood biochemistry, measured MDA, GSH contents in liver and performed classical histological examination of liver. The results showed that the acute elevation of serum ALT, AST due to APAP-induced hepatotoxicity were significantly restored in the groups receiving VG and PVG. Necrosis of liver significantly decreased according to histopathologic observation. PVG was significantly more effective against APAP-induced hepatotoxicity when compared with VG. It is concluded that both VG and PVG have protective effect on hepatotoxicity induced by APAP and that PVG has better effect than VG
Keywords: Vietnamese ginseng, Processed, Paracetamol, APAP.
(Nguồn tin: Tạp chí Dược liệu - Viện Dược liệu)