Tạp chí

Enniatin Derivatives from Fusarium sp. and their Biological Activities (Tạp chí Dược liệu, tập 22, số 3/2017)

Journal of Medicinal Materials, 2017, Vol. 22, No. 3 (pp.131-136)

ENNIATIN DERIVATIVES FROM FUSARIUM SP. AND THEIR BIOLOGICAL ACTIVITIES

Hoang Duc Manh¹, Nguyen Minh Khoi¹, Tran Minh Ngoc¹, Do Thi Ha¹,

Bo Yeon Kim², Jong Seog Ahn², Tran Manh Hung³^,*

¹National Institute of Medicinal Materials, Hanoi, Vietnam;

²Korea Research Institute of Bioscience and Biotechnology (KRIBB), 685-1 Yangcheonri, Ochangup, Cheongwongun 363-883, Korea;

³Biomedical Science Department, VNUK-Institute for Research & Executive Education, The University of Danang, Danang City, Vietnam

*Corresponding author: hung.tran@vnuk.edu.vn

(Received February, 06^th, 2017)

Summary

Enniatin Derivatives from Fusarium sp. and their Biological Activities

The genus Fusarium sp. has been reported to contain several phytochemical constituents with applicable pharmaceutical properties. In our experiment, bioassay-guided fractionation resulted in the isolation of eight compounds from the ethyl acetate-soluble extract of Fusarium sp. FN332 fungi broth. Their chemical structures were elucidated as enniatin B (1), enniatin H (2), enniatin A (3), enniatin F (4), enniatin I (5), MK 1688 (6), enniatin D (7), and enniatin G (8) on the basis of spectroscopic data. All the isolated compounds (1−8) inhibited PTP1B with IC₅₀ values ranging from 12.7 ± 0.5 to 35.5 ± 1.2 μM. Enniatin A (3) reduced the V_max value, but did not alter the Km value of PTP1B in kinetic action. Enniatin A (3) also stimulated the phosphorylation of AMPKα catalytic subunit in a dose-dependent manner. The results suggest that the enniatins from Fusarium sp. might be a considerable source of PTP1B inhibitor and AMPK phosphorylation activator.