Summary

Acute Toxycity, Analgesic, and Anti-inflammatory Activity of Venom

from Black Scorpion in Tay Ninh

Invertebrate venoms including scorpion ones have attracted considerable interest as a potential source of bioactive substances. Scorpion venom has been so far demonstrated to have many important pharmacological effects such as anti-inflammation, analgelsia, anticonsulvant…

In present study, the acute toxycity, analgesic and anti-inflammatory activities of the venoms extracted from Tay Ninh black scorpions Heterometrus sp. were investigated in mice by using s.c. injection. The animals were observed for 24 h after injection in order to evaluate lethal dose. The antinociceptive effect of the venoms was investigated by tail immersion test and acetic acid induced writhing test. The in vitro anti-inflammatory activity was investigated by carrageenin induced edema in hind paw of mice.

The LD₅₀ of  the black scorpion venom is 170±9,95 mg/Kg B.W. in mice (s.c.). Toxycity of black scorpion venom is classified as the third class toxycity. Back scorpion venom has not only central and peripheral analgesic effect in acetic acid induced writhing test and tail immersion test, but also anti-inflammatory effect in carrageenin induced inflammation test at the dosages 8,5 or 17 mg/Kg, s.c.

Keywords: analgesic activity; anti-inflammatory activity; Heterometrus sp.; LD₅₀; scorpion; venom

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