Tạp chí

CYTOTOXIC ACTIVITY OF ABIETANE-TYPE DITERPENES FROM SALVIA MILTIORRHIZA BUNGE CULTIVATED IN HA GIANG PROVINCE - Tạp chí Dược liệu, tập 21, số 5/2016

CYTOTOXIC ACTIVITY OF ABIETANE-TYPE DITERPENES FROM SALVIA MILTIORRHIZA BUNGE CULTIVATED IN HA GIANG PROVINCE - Journal of Medicinal Materials, 2016, Vol. 21, No. 5

CYTOTOXIC ACTIVITY OF ABIETANE-TYPE DITERPENES FROM SALVIA MILTIORRHIZA BUNGE CULTIVATED IN HA GIANG PROVINCE

Pham Thanh Binh1, Bui Thi Mai Anh1, Nguyen Hai Dang2, Pham Van Cuong1,2, Nguyen Van Hung1, Pham Thi Thu Hanh1, Nguyen The Cuong3, Luong Trieu Vung4, Giang Loc Thang5, Nguyen Tien Dat1,*

1Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST),

Hanoi, Vietnam;

2Advanced center for Bio-organic Chemistry, IMBC, VAST;

3Institute of Ecology and Biological Resources, VAST;

4Department of Agriculture and Rural Development of Ha Giang;

5Pho Bang Centre for Plant and Animal Varieties, Dong Van, Ha Giang

*Corresponding author: ngtiend@imbc.vast.vn

(Received September, 04th, 2016)

Summary

Cytotoxic Activity of Abietane-type Diterpenes from Salvia miltiorrhiza Bunge Cultivated in Ha Giang Province

A phytochemical fractionation of the methanol extract of the roots of Salvia miltiorrhiza cultivated in Ha Giang province led to the isolation of four abietane-type diterpenes, which were identified as 6,7-didehydroferruginol (1), ferruginol (2), tanshinone IIA (3), and sibiriquinone B (4). Compound 1 was identified for the first time from S. miltiorrhiza. All compounds were evaluated for their cytotoxicity against human lung carcinoma (A549, EGFR-TKI resistant, wild type), human breast carcinoma (MDA-MB-231), and human prostate carcinoma (DU145) cell lines. Compound 1 showed potent cytotoxic effect against EGFR-TKI resistant A549 cells with the IC50 value of 0.68 μM.

Keywords: Salvia miltiorrhiza, Abietane-type diterpene, 6,7-didehydroferruginol, EGFR-TKI resistant.

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