Evaluation of the Anti-Inflammatory Effects of Tetracera scandens on Peritonitis Model in Mice and Rats

The plant Tetracera scandens (L.) Merr., vernacularly known as “chặc chìu”, has long been used in traditional medicine for treatment of inflammation. In order to explain the folk uses in traditional medicine, the anti-inflammatory effects of this plant were evaluated on peritonitis models in mice and rats. The results showed that MeOH extract of T. scandens at the dose of 0.6 g/kg and EtOAc fraction at the doses of 0.3 g/kg and 0.6 g/kg exhibited remarkable decrease of exudation volume as well as protein level and leukocyte count of exudation as compared with the control group in both rats and mice. These observations demonstrate that the plant chac chiu has the acute anti-inflammatory effects, supporting the traditional uses of the plant in Vietnamese ethnomedicine. This work also suggests that mice, instead of rats, can be used for validation of anti-inflammatory activity of drugs by peritonitis model.

Keywords: Tetracera scandens, Anti-inflammatory effect, Peritonitis model, Mice.

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