\n\tSummary

\n\tAcute and Subchronic Toxicity of Anti-Hepatitis and Anti-Cirrhosis Hypatin from

\n\tHypericum patulum Thunb. ex Murray

\n\tA new anti-hepatitis and anti-cirrhosis herbal product  hypatin from Hypericum patulum Thunb. ex Murray has been experimentally evaluated for acute toxicity in mice and subchronic toxicity in rabbits by oral administration. The results of acute toxicity test indicated that  it’s impossible to determine LD₅₀ of the product and infralethal dose (LD₀) of hypatin is 5,0 g hypatin equivalent to 87,87 g dried raw material/kg body weight.

\n\tIn the subchronic toxicity study rabbits were orally given 0,5 g hypatin/kg body weight/per day for 30 days. The blood hematological and biochemical analysis  as well as histopathological examination of liver and kidney tissue showed no significant difference between treatment and control groups.

\n\tHypatin is safe for use.

\n\tKey words: Hypatin; Acute toxicity; subchronic toxicity, Hypericum patulum Thunb. ex Murray

(Nguồn tin: )