\n\tSummary

\n\tProtective Effect of Herbal Formulae on Alcohol-Induced Acute Hepatotoxicity in Mice 

\n\tWe investigated the protective effects of eight herbal formulae, namely CT1 to CT8, composed of the extracts of green tea leaves Camellia sinensis, the rhizome of Zingiber officinale and aerial parts of Plantago major on liver injury induced by acute ethanol administration.

\n\tMice were divided into 10 groups, control, ethanol treatment, and herbal formulae / ethanol treatment. Ethanol-treated mice received ethanol (5 g/kg) by gavage every 12 hours for a total of 3 doses. In the herbal formula/ethanol group, each formula were gavaged at a dose of 600 mg/kg for 7 days before ethanol treatment. At 4 hours after the last dosing, the mice were anesthetized and subsequent serum aminotransferases (ALT, AST), hepatic triglyceride levels were measured.

\n\tAcute ethanol administration caused an elevation of serum ALT activity, and increased hepatic triglyceride level. Pretreatment with  CT5 and CT7 attenuated these adverse changes induced by acute ethanol administration. These data indicated that CT5 and CT7 possessed ability to prevent ethanol-induced acute toxicity.

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\n\tKey words: Alcohol-induced acute hepatotoxicity; Camellia sinensis; Zingiber officinale, Plantago major.

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