SCREENING FOR CYTOTOXIC ACTIVITY OF THREE POLYGONUM SPECIES IN VIETNAM

Tran Thanh Ha ^1,2,*, Nguyen Van Dau ², Do Thi Ha¹, Tran Thi Hien³

¹National Institute of Medicinal Materials, Vietnam

²University of Natural Sciences - Vietnam National University, Hanoi, Vietnam

³Thai binh University of Medicine and Pharmacy, Vietnam

*Corresponding author: thanhha.tran889@gmail.com

(Received April, 28^th, 2016)

Summary

Screening for Cytotoxic Activity of three Polygonum Species

The cytotoxic activity of three Polygonum species including P. barbatum L., P. plebeium R.Br, P. perfoliatum L. gathered in Vietnam were investigated for the first time. Eleven extracts of different parts of three Polygonum species were evaluated for the cytotoxic activity against five human cancer cell lines, including HT-1080, MDA-MB 231, MCF-7/adr, MCF-7/TAMR, and Hela. Of these, the extracts of P. barbatum L., P. plebeium R.Br, and P. perfolium L. exhibited high potent cytotoxic activity showing a certain degree of selectivity against the indicated cancer cell lines, with IC₅₀ values ranging from 5.1 to 19.9 µg/mL.

Keywords: Cytotoxicity, Polygonum, Polygonum barbatum L., P. plebeium R.Br, P. perfoliatum L.