\n\t\tSummary

\n\t\tPeroxydase Activity and Sulfhydryl Group Content in Liver of Mice Exposed

\n\t\tto Dichlorodiethyl Sulfide by Percutaneous Route and Effects of

\n\t\tSodium Thiosulfate and Naturenz

\n\t\tPeroxydase and free sulfhydryl group (-SH) levels in mouse livers were determined at days 1^st, 7^th, 15^th and 30^th after mice was empoisoned by dichlorodiethyl sulfide (HD) with single dose of 1LD₅₀ by percutaneous route. Our results showed that, at the days 7^th, 15^th and 30^th after acute intoxication, peroxydase activity and -SH group concent in murine livers were significantly lower than those of the control group (p < 0,05); they werelowest at the day 7^th (redution 32.2% and 39.5% compared to control, respectively). Treatment with sodium thiosulfate alone increased considerably the -SH content but only at the days 7^th and 15^th while with Naturenz combined for 30 days (120 mg/kg daily), all disorders in peroxydase activity and -SH levels were completely resolved throughout the period of investigation.

\n\t\tKey words: dichlorodiethyl sulfide, peroxydase, sulfhydryl group, Naturenz.