Anti-Influenza Viral Activities of Constituents from Curcuma longa
Ten curcuminoids isolated from the rhizomes of Curcuma longa, had strong inhibitory effects on the neuraminidases from two influenza A viral strains, H1N1 and H9N2, as noncompetitive inhibitors with IC50 values ranging from 6.18 to 40.17 µg/mL and 3.77 to 31.82 µg/mL, respectively. They also exhibited significant inhibitory activity against the neuraminidases from novel influenza H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y mutant) expressed in 293T cells. In addition, the detailed relationships of structure and activity by the compounds were investigated.
Keywords: influenza A; H1N1; neuraminidase inhibitors; Curcuma longa; curcuminoids.
(Nguồn tin: )