Summary
Acute and 30 Days Subchronic Toxicity of Anastrozole
Anastrozole is an aromatase-inhibiting drug approved for treatment of advanced breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. Recently, we reported results on synthesis of anastrozole from mesitylen, a commercially available material. In this study, anastrozole was experimentally evaluated for acute and subchronic oral toxicity in mice and rabbits. The results indicated that LD50 of anastrozole in mice is 600.7 mg/kg body weight for single dose oral administration. In the 30 days subchronic study, rabbits were administrated anastrozole with the dose equivalent to 0.1 mg and 1 mg/kg/day for 30 days. After 15, 30 and 45 days, blood and tissue samples were taken for hematological, biochemical and histopathological determinations. All hematological, biochemical parameters and histopathological showed non-significant difference between treatment and control groups.
Keywords: anastrozole; acute toxicity; subchronic toxicity.
(Nguồn tin: )