Nguyen Thuy Duong1,*, Nguyen Quynh Chi1, Phuong Thien Thuong2, Nguyen Hoang Anh1
1Hanoi University of Pharmacy, Vietnam, 2National Institute of Medicinal Materials, Vietnam
*Corresponding author: firstname.lastname@example.org
(Received September, 20th, 2015)
Screening Vietnamese Medicinal Plants for Xanthine Oxidase Inhibitory Activity
Among 241 MeOH extracts, prepared from 238 plants, 184 extracts demonstrated xanthine oxidase inhibitory activity at 100 µg/ml.Of those, 66 extracts showed an inhibition rate greater than 50%. At 50 µg/ml, 128 extracts were active with 32 showed inhibition of XO more than 50%. At 10 µg/ml, 57 extracts were active with 5 possessing more than 50% inhibition. In total, 66 extracts showed IC50 values below 100 µg/ml. The crude extracts possessing XO inhibitory activity with IC50 values less than 10 µg/ml were extracts of Smilax corbularia Kunth (IC50 8.57 µg/ml), Dichroa febrifuga Lour. (IC50 8.58 µg/ml) and Miliusa balansae Fin.Gagnep. (IC50 9.40 µg/ml).
Keywords: Vietnamese medicinal plant, Xanthine oxidase inhibitory activity, Gout.
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